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Article Dans Une Revue International Journal of Molecular Sciences Année : 2020

Anti-inflammatory treatment with FTY720 starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model

Georgia-Ioanna Kartalou
  • Fonction : Auteur
Ana Rita Salgueiro Pereira
  • Fonction : Auteur
Thomas Endres
  • Fonction : Auteur
Angelina Lesnikova
  • Fonction : Auteur
Plinio Casarotto
  • Fonction : Auteur
Paula Pousinha
  • Fonction : Auteur
Kevin Delanoe
Elke Edelmann
  • Fonction : Auteur
Eero Castrén
Kurt Gottmann
  • Fonction : Auteur
Volkmar Lessmann

Résumé

Therapeutical approaches providing effective medication for Alzheimer’s disease (AD) patients after disease onset are urgently needed. Repurposing FDA approved drugs like fingolimod (FTY720) for treatment of AD is a promising way to reduce the time to bring such medication into clinical practice. Previous studies in AD mouse models suggested that physical exercise or changed lifestyle can delay AD related synaptic and memory dysfunctions when treatment started in juvenile animals long before onset of disease symptoms. Here, we addressed whether the FDA approved drug fingolimod rescues AD related synaptic deficits and memory dysfunction in an APP/PS1 AD mouse model when medication starts after onset of symptoms (at 5 months). Male mice received intraperitoneal injections of fingolimod for 1-2 months starting at 5-6 months. This treatment rescued spine density as well as long-term potentiation in hippocampal CA1 pyramidal neurons, and ameliorated dysfunctional hippocampus-dependent memory that was observed in untreated APP/PS1 animals at 6-7 months of age. Immunohistochemical analysis with markers of microgliosis (Iba1) and astrogliosis (GFAP) revealed that our fingolimod treatment regime strongly down regulated neuro-inflammation in the hippocampus and cortex of this AD model. These effects were accompanied by a moderate reduction of Aβ accumulation in hippocampus and cortex. Our results suggest that fingolimod, when applied after onset of disease symptoms in an APP/PS1 mouse model, rescues synaptic pathology and related memory performance deficits observed in untreated AD mice, and that this beneficial effect is mediated via anti-neuroinflammatory actions of the drug on microglia and astrocytes.
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Dates et versions

hal-03017159 , version 1 (20-11-2020)

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Georgia-Ioanna Kartalou, Ana Rita Salgueiro Pereira, Thomas Endres, Angelina Lesnikova, Plinio Casarotto, et al.. Anti-inflammatory treatment with FTY720 starting after onset of symptoms reverses synaptic and memory deficits in an AD mouse model. International Journal of Molecular Sciences, 2020, ⟨10.3390/ijms21238957⟩. ⟨hal-03017159⟩
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