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Microtubule-associated tumor suppressors as prognostic biomarkers in breast cancer

Abstract : Breast cancer is the most common malignancy in women worldwide. Although important therapeutic progress was achieved over the past decade, this disease remains a public health problem. In the light of precision medicine, the identification of new prognostic biomarkers in breast cancer is urgently needed to stratify populations of patients with poor clinical outcome who may benefit from new personalized therapies. The microtubule cytoskeleton plays a pivotal role in essential cellular functions and is an interesting target for cancer therapy. Microtubule assembly and dynamics are regulated by a wide range of microtubule-associated proteins (MAPs), some of which have oncogenic or tumor suppressors effects in breast cancer. This review covers current knowledge on microtubule-associated tumor suppressors (MATS) in breast cancer and their potential value as prognostic biomarkers. We present recent studies showing that combinatorial expression of ATIP3 and EB1, two microtubule-associated biomarkers with tumor suppressor and oncogenic effects, respectively, improves breast cancer prognosis compared to each biomarker alone. These findings are discussed regarding the increasing complexity of protein networks composed of MAPs that coordinate microtubule dynamics and functions. Further studies are warranted to evaluate the prognostic value of combined expression of different MATS and their interacting partners in breast cancer.
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Submitted on : Tuesday, November 24, 2020 - 4:59:10 PM
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Sylvie Rodrigues-Ferreira, Angie Molina, Clara Nahmias. Microtubule-associated tumor suppressors as prognostic biomarkers in breast cancer. Breast Cancer Research and Treatment, Springer Verlag, 2020, 179, pp.267-273. ⟨10.1007/s10549-019-05463-x⟩. ⟨hal-02411557⟩



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