Phenotypic differences between highlanders and lowlanders in Papua New Guinea

Mathilde André (1) , Sébastien Plutniak (2) , Nicolas Brucato (3) , Jason Kariwiga (4, 5) , John Muke , Adeline Morez (6) , Matthew Leavesley (4) , Mayukh Mondal (1) , Francois-Xavier Ricaut (3)

1 Institute of Genomics [Tartu, Estonia]
2 TRACES - Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés
3 EDB - Evolution et Diversité Biologique
4 UPNG - University of Papua New Guinea
5 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
6 LJMU - Liverpool John Moores University

Objectives Altitude is one of the most demanding environmental pressures for human populations. Highlanders from Asia, America and Africa have been shown to exhibit different biological adaptations, but Oceanian populations remain understudied [Woolcock et al., 1972; Cotes et al., 1974; Senn et al., 2010]. We tested the hypothesis that highlanders phenotypically differ from lowlanders in Papua New Guinea, as a result of inhabiting the highest mountains in Oceania for at least 20,000 years.Materials and methods We collected data for 13 different phenotypes related to altitude for 162 Papua New Guineans living at high altitude (Mont Wilhelm, 2,300–2,700 m above sea level (a.s.l.) and low altitude (Daru, <100m a.s.l.). Multilinear regressions were performed to detect differences between highlanders and lowlanders for phenotypic measurements related to body proportions, pulmonary function, and the circulatory system.Results Six phenotypes were significantly different between Papua New Guinean highlanders and lowlanders. Highlanders show shorter height (p-value = 0.001), smaller waist circumference (p-value = 0.002), larger Forced Vital Capacity (FVC) (p-value = 0.008), larger maximal (p-value = 3.20e -4) and minimal chest depth (p-value = 2.37e -5) and higher haemoglobin concentration (p-value = 3.36e -4).Discussion Our study reports specific phenotypes in Papua New Guinean highlanders potentially related to altitude adaptation. Similar to other human groups adapted to high altitude, the evolutionary history of Papua New Guineans appears to have also followed an adaptive biological strategy for altitude.

Domaines: Anthropologie biologique

Mathilde André, Sébastien Plutniak, Nicolas Brucato, Jason Kariwiga, John Muke, et al.. Phenotypic differences between highlanders and lowlanders in Papua New Guinea. PLoS ONE, 2021, 16 (7), ⟨10.1371/journal.pone.0253921⟩. ⟨hal-03318156⟩